| | Category | ME | L15 | Does Sleep Apnea itself or the increased arousals in sleep cause |
| | Nocturia? |
| | Abstract | Many patients who have sleep apnea, snoring, restless legs at night |
| | (periodic limb movements) and pain have interrupted sleep with frequent |
| | mini arousals. Many of these patients , but not all, have nocturia (wake up |
| | to urinate in night). Available research in the sleep field of medicine shows |
| | some correlation between sleep apnea and nocturia. It was proposed that |
| | disturbances of abdominal pressure in sleep apnea, noise of snoring and |
| | interrupted secretion of antidiuretic hormone (ADH) from the hypothalamus |
| | contributes to nocturia. It is not clear why some have less nocturia then |
| | others for similar amounts of sleep apnea at night. This study is to prove |
| | the hypothesis that it is the extent of arousals that more directly correlates |
| | to nocturia. The sleep apnea, snoring, periodic limb movements indirectly |
| | correlate to nocturia, depending on arousals secondary to the individual’s |
| | threshold for arousals. Those with higher threshold for arousal (in thalamic |
| | sensory gateway) are less disrupted in production ADH and less |
| | nocturia. Data will be gathered retrospectively. The data collected will be |
| | of adult patients who had overnight sleep studies for sleep disorders |
| | including sleep apnea, periodic limb movements, snoring and other causes |
| | of sleep disruption. Data collected will include number of nocturia, |
| | frequency of arousals, frequency of sleep apnea, frequency of periodic |
| | limb movements, frequency of snoring, associated arousals, total sleep |
| | time, quantity and ratio of slow wave sleep and REM sleep. Data obtained |
| | will be correlated to test the hypothesis. |
| | This is a retrospective study of data gathered from routine clinical patient |
| | records after deidentification of all personal information. All privacy |
| | requirements of HIPPA will be adhered to under supervision of the HIPPA |
| | officer of the Sleep Center. There will be no effect on any patient's care or |
| | health due to this study. |
| | Bibliography | Martin John H. PhD ; Neuroanatomy text and atlas third edition, 2003. |
| | McGraw Hills. |